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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868
Species: Homo sapiens
RGD Object: Gene
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:8653
Term: pyocyanine
Definition: An iminium betaine that is 5-methylphenazin-5-ium which is substituted at position 1 by an oxidanidyl group. An antibiotic pigment produced by Pseudomonas aeruginosa.
Chemical ID: MESH:D011710
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDPyocyanine results in increased expression of NQO1 mRNA

PMID:24015256
multiple interactionsEXP 6480464CTD[Pyocyanine results in increased localization of NFE2L2 protein] which results in increased expression of NQO1 mRNA, trigonelline inhibits the reaction [Pyocyanine results in increased expression of NQO1 mRNA]

PMID:24015256
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.