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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1345007
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP2E1
Name: cytochrome P450 family 2 subfamily E member 1
Acc ID: CHEBI:8633
Term: puerarin
Definition: A hydroxyisoflavone that is isoflavone substituted by hydroxy groups at positions 7 and 4' and a beta-D-glucopyranosyl residue at position 8 via a C-glycosidic linkage.
Chemical ID: MESH:C033607
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP2E1increases expressionISOCyp2e1 (Mus musculus)6480464CTDpuerarin results in increased expression of CYP2E1 proteinPMID:18038910
CYP2E1multiple interactionsISOCyp2e1 (Mus musculus)6480464CTDpuerarin inhibits the reaction [CYP2E1 protein results in increased hydroxylation of aniline]PMID:18038910
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