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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733892
Species: Mus musculus
RGD Object: Gene
Symbol: Gsk3b
Name: glycogen synthase kinase 3 beta
Acc ID: CHEBI:86290
Term: 6-bromoindirubin-3'-oxime
Definition: A member of the class of biindoles that is indirubin substituted at position 6 by a bromo group and in which the keto group at position 3' has undergone condensation with hydroxylamine to form the corresponding oxime.
Chemical ID: MESH:C483321
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsk3bmultiple interactionsEXP 6480464CTD[trametinib co-treated with 6-bromoindirubin-3'-oxime] affects the phosphorylation of GSK3B proteinPMID:37116855
Gsk3bdecreases activityISOGSK3B (Homo sapiens)6480464CTD6-bromoindirubin-3'-oxime results in decreased activity of GSK3B proteinPMID:17991738
Gsk3bincreases phosphorylationISOGSK3B (Homo sapiens)6480464CTD6-bromoindirubin-3'-oxime results in increased phosphorylation of GSK3B proteinPMID:19727391
Gsk3bmultiple interactionsISOGSK3B (Homo sapiens)6480464CTD6-bromoindirubin-3'-oxime promotes the reaction [Paraquat inhibits the reaction [TNFRSF10B protein binds to GSK3B protein]]; 6-bromoindirubin-3'-oxime promotes the reaction [Paraquat results in decreased expression of GSK3B protein modified form]; Methotrexate promotes the reaction [6-bromoindirubin-3'-oxime results in increased phosphorylation of GSK3B protein]PMID:19727391 PMID:28414160
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