GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Gsk3b | multiple interactions | EXP | | 6480464 | CTD | [trametinib co-treated with 6-bromoindirubin-3'-oxime] affects the phosphorylation of GSK3B protein | PMID:37116855 | Gsk3b | decreases activity | ISO | GSK3B (Homo sapiens) | 6480464 | CTD | 6-bromoindirubin-3'-oxime results in decreased activity of GSK3B protein | PMID:17991738 | Gsk3b | increases phosphorylation | ISO | GSK3B (Homo sapiens) | 6480464 | CTD | 6-bromoindirubin-3'-oxime results in increased phosphorylation of GSK3B protein | PMID:19727391 | Gsk3b | multiple interactions | ISO | GSK3B (Homo sapiens) | 6480464 | CTD | 6-bromoindirubin-3'-oxime promotes the reaction [Paraquat inhibits the reaction [TNFRSF10B protein binds to GSK3B protein]]; 6-bromoindirubin-3'-oxime promotes the reaction [Paraquat results in decreased expression of GSK3B protein modified form]; Methotrexate promotes the reaction [6-bromoindirubin-3'-oxime results in increased phosphorylation of GSK3B protein] | PMID:19727391 PMID:28414160 | |
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