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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737367
Species: Homo sapiens
RGD Object: Gene
Symbol: NOTCH1
Name: notch receptor 1
Acc ID: CHEBI:86193
Term: DAPT
Definition: A dipeptide consisting of alanylphenylglycine derivatised as a 3,5-difluorophenylacetamide at the amino terminal and a tert-butyl ester at the carboxy terminal. A gamma-secretase inhibitor.
Chemical ID: MESH:C419410
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NOTCH1decreases expressionEXP 6480464CTDN-N-3 5-difluorophenacetylalanylphenylglycine tert-butyl ester results in decreased expression of NOTCH1 protein modified form

PMID:18633435
NOTCH1multiple interactionsEXP 6480464CTDN-N-3 5-difluorophenacetylalanylphenylglycine tert-butyl ester inhibits the reaction [4-amino-2-trifluoromethyl-phenyl retinate results in increased expression of NOTCH1 protein] N-N-3 5-difluorophenacetylalanylphenylglycine tert-butyl ester inhibits the reaction [Cadmium Chloride results in increased cleavage of NOTCH1 protein] N-N-3 5-difluorophenacetylalanylphenylglycine tert-butyl ester inhibits the reaction [Hydrogen Peroxide results in increased cleavage of NOTCH1 protein] N-N-3 5-difluorophenacetylalanylphenylglycine tert-butyl ester inhibits the reaction [phenethyl isothiocyanate results in increased cleavage of and results in increased activity of NOTCH1 protein] N-N-3 5-difluorophenacetylalanylphenylglycine tert-butyl ester inhibits the reaction [polyhexamethyleneguanidine results in increased cleavage of NOTCH1 protein] N-N-3 5-difluorophenacetylalanylphenylglycine tert-butyl ester promotes the reaction [1 3-dihydro-1-1-4-6-phenyl-1H-imidazo4 5-gquinoxalin-7-ylphenylmethyl-4-piperidinyl-2H-benzimidazol-2-one inhibits the reaction [polyhexamethyleneguanidine results in increased cleavage of NOTCH1 protein]] N-N-3 5-difluorophenacetylalanylphenylglycine tert-butyl ester results in decreased cleavage of and results in decreased activity of NOTCH1 protein

PMID:22039516 PMID:25108166 PMID:25118938 PMID:28130038 PMID:31348943
NOTCH1multiple interactionsISORGD:109986480464CTDN-N-3 5-difluorophenacetylalanylphenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency affects the localization of NOTCH1 protein modified form] N-N-3 5-difluorophenacetylalanylphenylglycine tert-butyl ester inhibits the reaction [Tunicamycin results in increased cleavage of NOTCH1 protein] N-N-3 5-difluorophenacetylalanylphenylglycine tert-butyl ester promotes the reaction [Oxygen deficiency results in increased expression of NOTCH1 protein]

PMID:22115781 PMID:24223152
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