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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70502
Species: Homo sapiens
RGD Object: Gene
Symbol: TP53
Name: tumor protein p53
Acc ID: CHEBI:86193
Term: DAPT
Definition: A dipeptide consisting of alanylphenylglycine derivatised as a 3,5-difluorophenylacetamide at the amino terminal and a tert-butyl ester at the carboxy terminal. A gamma-secretase inhibitor.
Chemical ID: MESH:C419410
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TP53decreases expressionEXP 6480464CTDN-N-3 5-difluorophenacetylalanylphenylglycine tert-butyl ester results in decreased expression of TP53 protein

PMID:25005833
TP53multiple interactionsEXP 6480464CTDHydrogen Peroxide inhibits the reaction [N-N-3 5-difluorophenacetylalanylphenylglycine tert-butyl ester results in decreased expression of TP53 protein]

PMID:25005833
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