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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1354394
Species: Homo sapiens
RGD Object: Gene
Symbol: KRT10
Name: keratin 10
Acc ID: CHEBI:86193
Term: DAPT
Definition: A dipeptide consisting of alanylphenylglycine derivatised as a 3,5-difluorophenylacetamide at the amino terminal and a tert-butyl ester at the carboxy terminal. A gamma-secretase inhibitor.
Chemical ID: MESH:C419410
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
KRT10decreases expressionEXP 6480464CTDN-N-3 5-difluorophenacetylalanylphenylglycine tert-butyl ester results in decreased expression of KRT10 mRNA N-N-3 5-difluorophenacetylalanylphenylglycine tert-butyl ester results in decreased expression of KRT10 protein

PMID:18633435
KRT10multiple interactionsEXP 6480464CTDN-N-3 5-difluorophenacetylalanylphenylglycine tert-butyl ester inhibits the reaction [BMP6 protein results in increased expression of KRT10 mRNA] N-N-3 5-difluorophenacetylalanylphenylglycine tert-butyl ester inhibits the reaction [U 0126 results in increased expression of KRT10 mRNA]

PMID:23566955
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