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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1354369
Species: Homo sapiens
RGD Object: Gene
Symbol: HEY2
Name: hes related family bHLH transcription factor with YRPW motif 2
Acc ID: CHEBI:86193
Term: DAPT
Definition: A dipeptide consisting of alanylphenylglycine derivatised as a 3,5-difluorophenylacetamide at the amino terminal and a tert-butyl ester at the carboxy terminal. A gamma-secretase inhibitor.
Chemical ID: MESH:C419410
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HEY2multiple interactionsEXP 6480464CTDN-N-3 5-difluorophenacetylalanylphenylglycine tert-butyl ester inhibits the reaction [baicalein results in increased expression of HEY2 mRNA] N-N-3 5-difluorophenacetylalanylphenylglycine tert-butyl ester inhibits the reaction [baicalin results in increased expression of HEY2 mRNA] N-N-3 5-difluorophenacetylalanylphenylglycine tert-butyl ester inhibits the reaction [Niclosamide results in increased expression of HEY2 mRNA]

PMID:19160421
HEY2multiple interactionsISORGD:6214056480464CTDN-N-3 5-difluorophenacetylalanylphenylglycine tert-butyl ester inhibits the reaction [tetrabromobisphenol A results in increased expression of HEY2 mRNA]

PMID:32041402
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