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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1348351
Species: Homo sapiens
RGD Object: Gene
Symbol: ACTA2
Name: actin alpha 2, smooth muscle
Acc ID: CHEBI:86193
Term: DAPT
Definition: A dipeptide consisting of alanylphenylglycine derivatised as a 3,5-difluorophenylacetamide at the amino terminal and a tert-butyl ester at the carboxy terminal. A gamma-secretase inhibitor.
Chemical ID: MESH:C419410
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ACTA2multiple interactionsEXP 6480464CTD1 3-dihydro-1-1-4-6-phenyl-1H-imidazo4 5-gquinoxalin-7-ylphenylmethyl-4-piperidinyl-2H-benzimidazol-2-one promotes the reaction [N-N-3 5-difluorophenacetylalanylphenylglycine tert-butyl ester inhibits the reaction [polyhexamethyleneguanidine results in increased expression of ACTA2 protein]] N-N-3 5-difluorophenacetylalanylphenylglycine tert-butyl ester inhibits the reaction [polyhexamethyleneguanidine results in increased expression of ACTA2 protein] N-N-3 5-difluorophenacetylalanylphenylglycine tert-butyl ester promotes the reaction [1 3-dihydro-1-1-4-6-phenyl-1H-imidazo4 5-gquinoxalin-7-ylphenylmethyl-4-piperidinyl-2H-benzimidazol-2-one inhibits the reaction [polyhexamethyleneguanidine results in increased expression of ACTA2 protein]]

PMID:31348943
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