GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cdk6 | increases expression | ISO | CDK6 (Homo sapiens) | 6480464 | CTD | palbociclib results in increased expression of CDK6 protein | PMID:20473330 PMID:22869556 PMID:23138228 | Cdk6 | multiple interactions | ISO | CDK6 (Homo sapiens) | 6480464 | CTD | palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of MEF2D protein]; palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of RB1 protein]; palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of RBL2 protein]; palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of SENP3 protein]; palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of ZEB1 protein]; palbociclib inhibits the reaction [CDC37 protein binds to CDK6 protein] | PMID:22094256 PMID:29091774 | Cdk6 | multiple interactions | ISO | Cdk6 (Mus musculus) | 6480464 | CTD | [CDKN2A gene mutant form results in increased expression of CDK6 protein] which results in increased susceptibility to palbociclib | PMID:24098593 | | ||||||||||||||||||||||
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