GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Plk1 | decreases expression | ISO | PLK1 (Homo sapiens) | 6480464 | CTD | palbociclib results in decreased expression of PLK1 mRNA | PMID:22869556 | Plk1 | multiple interactions | ISO | PLK1 (Homo sapiens) | 6480464 | CTD | palbociclib inhibits the reaction [RBL1 protein binds to PLK1 promoter]; RB1 protein affects the reaction [palbociclib inhibits the reaction [RBL1 protein binds to PLK1 promoter]] | PMID:20100483 | |
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