GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cdkn2a | increases response to substance | EXP | | 6480464 | CTD | CDKN2A gene mutant form results in increased susceptibility to palbociclib | PMID:24098593 | Cdkn2a | multiple interactions | EXP | | 6480464 | CTD | [CDKN2A gene mutant form results in increased expression of CCND1 protein] which results in increased susceptibility to palbociclib; [CDKN2A gene mutant form results in increased expression of CCND2 protein] which results in increased susceptibility to palbociclib; [CDKN2A gene mutant form results in increased expression of CCND3 protein] which results in increased susceptibility to palbociclib; [CDKN2A gene mutant form results in increased expression of CDK4 protein] which results in increased susceptibility to palbociclib; [CDKN2A gene mutant form results in increased expression of CDK6 protein] which results in increased susceptibility to palbociclib; [CDKN2A gene mutant form results in increased susceptibility to palbociclib] which affects the activity of CASP3 protein; [CDKN2A gene mutant form results in increased susceptibility to palbociclib] which affects the activity of CASP7 protein; [CDKN2A gene mutant form results in increased susceptibility to palbociclib] which results in decreased phosphorylation of RB1 protein | PMID:24098593 | Cdkn2a | affects response to substance | ISO | CDKN2A (Homo sapiens) | 6480464 | CTD | CDKN2A gene modified form affects the susceptibility to palbociclib; CDKN2A gene mutant form affects the susceptibility to palbociclib; CDKN2A protein affects the susceptibility to palbociclib | PMID:24495407 | Cdkn2a | decreases response to substance | ISO | CDKN2A (Homo sapiens) | 6480464 | CTD | CDKN2A protein results in decreased susceptibility to palbociclib | PMID:21278246 PMID:22711607 | Cdkn2a | increases response to substance | ISO | CDKN2A (Homo sapiens) | 6480464 | CTD | CDKN2A gene mutant form results in increased susceptibility to palbociclib | PMID:21278246 | Cdkn2a | multiple interactions | ISO | CDKN2A (Homo sapiens) | 6480464 | CTD | [CDKN2A protein co-treated with CDKN2C protein] affects the susceptibility to palbociclib | PMID:20534551 | | ||||||||||||||||||||||
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