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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736378
Species: Homo sapiens
RGD Object: Gene
Symbol: APOE
Name: apolipoprotein E
Acc ID: CHEBI:85966
Term: ivabradine
Definition: A member of the class of benzazepines that is 7,8-dimethoxy-1,3,4,5-tetrahydro-3-benzazepin-2-one in which the amide hydrogen is replaced by a [{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)amino]propyl} group. Used (as its hydrochloride salt) to treat patients with angina who have intolerance to beta blockers and/or heart failure.
Chemical ID: MESH:C088408
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
APOEaffects response to substanceISOApoe (Mus musculus)6480464CTDAPOE affects the susceptibility to ivabradinePMID:21821843
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