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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732101
Species: Homo sapiens
RGD Object: Gene
Symbol: KCNH2
Name: potassium voltage-gated channel subfamily H member 2
Acc ID: CHEBI:85161
Term: palonosetron
Definition: An organic heterotricyclic compound that is an antiemetic used (as its hydrochloride salt) in combination with netupitant (under the trade name Akynzeo) to treat nausea and vomiting in patients undergoing cancer chemotherapy.
Chemical ID: MESH:C083418
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
KCNH2decreases activityEXP 6480464CTDpalonosetron results in decreased activity of KCNH2 proteinPMID:28551711
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