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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1318374
Species: Homo sapiens
RGD Object: Gene
Symbol: SIRT1
Name: sirtuin 1
Acc ID: CHEBI:85078
Term: dapagliflozin
Definition: A C-glycosyl comprising beta-D-glucose in which the anomeric hydroxy group is replaced by a 4-chloro-3-(4-ethoxybenzyl)phenyl group. Used (in the form of its propanediol monohydrate) to improve glycemic control, along with diet and exercise, in adults with type 2 diabetes.
Chemical ID: MESH:C529054
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SIRT1multiple interactionsISOSirt1 (Rattus norvegicus)6480464CTD[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of SIRT1 protein]; dapagliflozin inhibits the reaction [IL1B protein results in decreased expression of SIRT1 mRNA]; dapagliflozin inhibits the reaction [IL1B protein results in decreased expression of SIRT1 protein]; Thapsigargin inhibits the reaction [dapagliflozin inhibits the reaction [IL1B protein results in decreased expression of SIRT1 mRNA]]PMID:34939712 PMID:37741535
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