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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735466
Species: Mus musculus
RGD Object: Gene
Symbol: Jag1
Name: jagged 1
Acc ID: CHEBI:8502
Term: 6-propyl-2-thiouracil
Definition: A pyrimidinethione consisting of uracil in which the 2-oxo group is substituted by a thio group and the hydrogen at position 6 is substituted by a propyl group.
Chemical ID: MESH:D011441
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Jag1decreases expressionISOJag1 (Rattus norvegicus)6480464CTDPropylthiouracil results in decreased expression of JAG1 mRNAPMID:30047161
Jag1increases expressionISOJag1 (Rattus norvegicus)6480464CTDPropylthiouracil results in increased expression of JAG1 mRNAPMID:25825206
Jag1multiple interactionsISOJAG1 (Homo sapiens)6480464CTDPropylthiouracil inhibits the reaction [Monocrotaline results in increased expression of JAG1 protein]PMID:36942326
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