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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733214
Species: Mus musculus
RGD Object: Gene
Symbol: Tpo
Name: thyroid peroxidase
Acc ID: CHEBI:8502
Term: 6-propyl-2-thiouracil
Definition: A pyrimidinethione consisting of uracil in which the 2-oxo group is substituted by a thio group and the hydrogen at position 6 is substituted by a propyl group.
Chemical ID: MESH:D011441
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tpodecreases activityISOTpo (Rattus norvegicus)6480464CTDPropylthiouracil results in decreased activity of TPO proteinPMID:22342233 PMID:23959146 PMID:26884060 PMID:28973696 PMID:31629072 PMID:31697382
Tpodecreases activityISOTPO (Homo sapiens)6480464CTDPropylthiouracil results in decreased activity of TPO proteinPMID:22342233 PMID:31629072
Tpodecreases expressionISOTPO (Homo sapiens)6480464CTDPropylthiouracil results in decreased expression of TPO mRNAPMID:22342233
Tpoincreases expressionISOTpo (Rattus norvegicus)6480464CTDPropylthiouracil results in increased expression of TPO mRNAPMID:22342233
Tpomultiple interactionsISOTpo (Rattus norvegicus)6480464CTD[Propylthiouracil results in decreased activity of TPO protein] which results in decreased chemical synthesis of and results in decreased abundance of ThyroxinePMID:28973696
Tpomultiple interactionsISOTPO (Homo sapiens)6480464CTDPropylthiouracil binds to and results in decreased activity of TPO proteinPMID:26865668
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