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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736366
Species: Homo sapiens
RGD Object: Gene
Symbol: REN
Name: renin
Acc ID: CHEBI:8499
Term: propranolol
Definition: A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.
Chemical ID: MESH:D011433
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
RENdecreases activityEXP 6480464CTDPropranolol results in decreased activity of REN proteinPMID:1103606 PMID:6346849 PMID:637424 PMID:791319 PMID:7988622
RENdecreases expressionEXP 6480464CTDPropranolol results in decreased expression of REN proteinPMID:200433 PMID:653302
RENmultiple interactionsEXP 6480464CTDPropranolol affects the reaction [Anesthetics, Combined results in increased activity of REN protein]; Propranolol affects the reaction [Nitroprusside promotes the reaction [Anesthetics, Combined results in increased activity of REN protein]]; Propranolol inhibits the reaction [Isoproterenol results in increased expression of REN protein]; Propranolol inhibits the reaction [Nitroprusside results in increased activity of REN protein]; Propranolol inhibits the reaction [REN protein results in increased cleavage of AGT protein]PMID:1653766 PMID:6434220 PMID:7020487 PMID:7104148
RENdecreases activityISORen (Rattus norvegicus)6480464CTDPropranolol results in decreased activity of REN proteinPMID:145319 PMID:6110712
RENmultiple interactionsISORen (Rattus norvegicus)6480464CTDPropranolol inhibits the reaction [ioxitalamic acid results in increased expression of REN protein]; Propranolol inhibits the reaction [Prazosin results in increased transport of REN protein]; Propranolol inhibits the reaction [Yohimbine results in increased expression of REN protein]PMID:19945959 PMID:3539430 PMID:6323192
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