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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69423
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Srebf1
Name: sterol regulatory element binding transcription factor 1
Acc ID: CHEBI:8489
Term: propiconazole
Definition: The cyclic ketal obtained by formal condensation of 1-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone with pentane-1,2-diol. A triazole fungicide, it is used commercially as a diastereoisomeric mixture on soft fruit (including apricots, peaches, nectarines, plums and prunes), nuts (including peanuts, pecans and almonds), mushrooms, and grasses grown for seeds.
Chemical ID: MESH:C045950
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:694736480464CTDpropiconazole results in decreased expression of SREBF1 mRNA

PMID:30989312
decreases expressionISORGD:694746480464CTDpropiconazole results in decreased expression of SREBF1 mRNA

PMID:21278054
multiple interactionsISORGD:694736480464CTD[propiconazole co-treated with tebuconazole] results in increased expression of SREBF1 mRNA

PMID:30989312
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.