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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61964
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gstm5
Name: glutathione S-transferase, mu 5
Acc ID: CHEBI:8489
Term: propiconazole
Definition: The cyclic ketal obtained by formal condensation of 1-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone with pentane-1,2-diol. A triazole fungicide, it is used commercially as a diastereoisomeric mixture on soft fruit (including apricots, peaches, nectarines, plums and prunes), nuts (including peanuts, pecans and almonds), mushrooms, and grasses grown for seeds.
Chemical ID: MESH:C045950
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gstm5increases expressionEXP 6480464CTDpropiconazole results in increased expression of GSTM3 mRNAPMID:16643972
Gstm5increases expressionISOGstm5 (Mus musculus)6480464CTDpropiconazole results in increased expression of GSTM3 mRNAPMID:21278054 PMID:22334560 PMID:23970803 PMID:25949234
Gstm5multiple interactionsISOGstm5 (Mus musculus)6480464CTDNR1H3 gene mutant form promotes the reaction [propiconazole results in increased expression of GSTM3 mRNA]PMID:25949234
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