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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736217
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP2D6
Name: cytochrome P450 family 2 subfamily D member 6
Acc ID: CHEBI:8455
Term: proguanil
Definition: A biguanide compound which has isopropyl and p-chlorophenyl substituents on the terminal N atoms. A prophylactic antimalarial drug, it works by inhibiting the enzyme dihydrofolate reductase, which is involved in the reproduction of the malaria parasites Plasmodium falciparum and P. vivax within the red blood cells.
Chemical ID: MESH:D002727
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP2D6decreases activityEXP 6480464CTDProguanil results in decreased activity of CYP2D6 proteinPMID:11124226
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