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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3046
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk3
Name: mitogen activated protein kinase 3
Acc ID: CHEBI:84500
Term: varenicline
Definition: An organic heterotetracyclic compound that acts as a partial agonist for nicotinic cholinergic receptors and is used (in the form of its tartate salt) as an aid to giving up smoking.
Chemical ID: MESH:D000068580
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk3decreases activityISORGD:6195706480464CTDVarenicline results in decreased activity of MAPK3 protein

PMID:28842382
Mapk3increases phosphorylationISORGD:6195716480464CTDVarenicline results in increased phosphorylation of MAPK3 protein

PMID:28202387
Mapk3multiple interactionsISORGD:6195706480464CTDmethyllycaconitine inhibits the reaction [Varenicline results in increased phosphorylation of MAPK3 protein]

PMID:28842382
Mapk3multiple interactionsISORGD:6195716480464CTDmethyllycaconitine inhibits the reaction [Varenicline results in increased phosphorylation of MAPK3 protein]

PMID:28202387
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