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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2345
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Chrna3
Name: cholinergic receptor nicotinic alpha 3 subunit
Acc ID: CHEBI:84500
Term: varenicline
Definition: An organic heterotetracyclic compound that acts as a partial agonist for nicotinic cholinergic receptors and is used (in the form of its tartate salt) as an aid to giving up smoking.
Chemical ID: MESH:D000068580
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chrna3multiple interactionsEXP 6480464CTDVarenicline binds to and results in increased activity of [CHRNA3 protein binds to CHRNB2 protein], Varenicline binds to and results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]

PMID:16766716
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.