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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2891
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il1b
Name: interleukin 1 beta
Acc ID: CHEBI:84491
Term: poly(I:C)
Definition: A mismatched double-stranded RNA with one strand being a polymer of inosinic acid, the other a polymer of cytidylic acid.
Chemical ID: MESH:D011070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1bincreases expressionEXP 6480464CTDPoly I-C results in increased expression of IL1B mRNAPMID:23939143
Il1bincreases expressionISOIl1b (Mus musculus)6480464CTDPoly I-C results in increased expression of IL1B mRNA; Poly I-C results in increased expression of IL1B proteinPMID:17321468 PMID:19500611 PMID:22771370 PMID:25780039 PMID:28316773
Il1bincreases expressionISOIL1B (Homo sapiens)6480464CTDPoly I-C results in increased expression of IL1B mRNA; Poly I-C results in increased expression of IL1B proteinPMID:27783115 PMID:30017638
Il1bincreases secretionISOIL1B (Homo sapiens)6480464CTDPoly I-C results in increased secretion of IL1B proteinPMID:23618096
Il1bmultiple interactionsISOIl1b (Mus musculus)6480464CTDAPPL1 protein inhibits the reaction [Poly I-C results in increased expression of IL1B protein]; Citrinin inhibits the reaction [Poly I-C results in increased expression of IL1B mRNA]; Ethanol inhibits the reaction [Poly I-C results in increased expression of IL1B protein]; Poly I-C promotes the reaction [deoxynivalenol results in increased expression of IL1B mRNA]PMID:16687389 PMID:19500611 PMID:22771370 PMID:25780039
Il1bmultiple interactionsISOIL1B (Homo sapiens)6480464CTD2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane promotes the reaction [Poly I-C results in increased expression of IL1B protein]; 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol promotes the reaction [Poly I-C results in increased expression of IL1B protein]; 6-formylindolo(3,2-b)carbazole promotes the reaction [Poly I-C results in increased expression of IL1B mRNA]; Estradiol promotes the reaction [Poly I-C results in increased expression of IL1B protein]; Tetrachlorodibenzodioxin promotes the reaction [Poly I-C results in increased expression of IL1B mRNA]PMID:27783115 PMID:30017638
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