GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | CXCL8 | increases expression | EXP | | 6480464 | CTD | Poly I-C results in increased expression of CXCL8; Poly I-C results in increased expression of CXCL8 mRNA; Poly I-C results in increased expression of CXCL8 protein | PMID:18779317 PMID:23688403 PMID:24709138 PMID:26456670 PMID:30017638 | CXCL8 | increases secretion | EXP | | 6480464 | CTD | Poly I-C results in increased secretion of CXCL8 protein | PMID:17669408 PMID:20932985 PMID:23618096 PMID:26160521 PMID:34843883 PMID:35817128 | CXCL8 | multiple interactions | EXP | | 6480464 | CTD | 1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [Estradiol promotes the reaction [Poly I-C results in increased expression of CXCL8 protein]]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane promotes the reaction [Poly I-C results in increased expression of CXCL8 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Poly I-C results in increased secretion of CXCL8 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Poly I-C results in increased secretion of CXCL8 protein]; 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol promotes the reaction [Poly I-C results in increased expression of CXCL8 protein]; [Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; CpG ODN 2006 inhibits the reaction [Poly I-C results in increased secretion of CXCL8 protein]; Estradiol promotes the reaction [Poly I-C results in increased expression of CXCL8 protein]; helenalin inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; IL4 protein promotes the reaction [Poly I-C results in increased expression of CXCL8 mRNA]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide inhibits the reaction [Poly I-C results in increased secretion of CXCL8 protein]; Particulate Matter promotes the reaction [Poly I-C results in increased expression of CXCL8]; Poly I-C affects the reaction [Gold Sodium Thiosulfate results in increased secretion of CXCL8 protein]; pyrazolanthrone inhibits the reaction [Poly I-C results in increased secretion of CXCL8 protein]; RTKI cpd inhibits the reaction [Poly I-C results in increased secretion of CXCL8 protein]; SB 203580 inhibits the reaction [Poly I-C results in increased secretion of CXCL8 protein]; Smoke inhibits the reaction [Poly I-C results in increased secretion of CXCL8 protein]; Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; TLR3 protein affects the reaction [Poly I-C results in increased expression of CXCL8 mRNA]; TP53 protein affects the reaction [Poly I-C results in increased expression of CXCL8 mRNA]; Vehicle Emissions promotes the reaction [Poly I-C results in increased expression of CXCL8]; Vehicle Emissions promotes the reaction [Poly I-C results in increased secretion of CXCL8 protein] | PMID:18779317 PMID:20932985 PMID:23688403 PMID:24709138 PMID:25458486 PMID:26160521 PMID:30017638 PMID:35817128 | |
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