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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1321144
Species: Homo sapiens
RGD Object: Gene
Symbol: ISG15
Name: ISG15 ubiquitin like modifier
Acc ID: CHEBI:84491
Term: poly(I:C)
Definition: A mismatched double-stranded RNA with one strand being a polymer of inosinic acid, the other a polymer of cytidylic acid.
Chemical ID: MESH:D011070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ISG15increases expressionEXP 6480464CTDPoly I-C results in increased expression of ISG15 mRNAPMID:31154625
ISG15multiple interactionsEXP 6480464CTDIRF7 protein mutant form inhibits the reaction [Poly I-C results in increased expression of ISG15 mRNA]; Nicotine inhibits the reaction [Poly I-C results in increased expression of ISG15 mRNA]PMID:31154625
ISG15increases expressionISOIsg15 (Mus musculus)6480464CTDPoly I-C results in increased expression of ISG15 mRNAPMID:36958387
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