GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Tnf | increases expression | EXP | | 6480464 | CTD | Poly I-C results in increased expression of TNF mRNA; Poly I-C results in increased expression of TNF protein | PMID:17238832 PMID:17321468 PMID:18323514 PMID:19426678 PMID:19500611 PMID:22319556 PMID:22771370 PMID:25780039 PMID:28316773 PMID:30726814 PMID:30836164 PMID:36958387 | Tnf | increases secretion | EXP | | 6480464 | CTD | Poly I-C results in increased secretion of TNF protein | PMID:17868967 PMID:22319556 | Tnf | multiple interactions | EXP | | 6480464 | CTD | APPL1 protein inhibits the reaction [Poly I-C results in increased expression of TNF protein]; Citrinin inhibits the reaction [Poly I-C results in increased expression of TNF mRNA]; Citrinin inhibits the reaction [Poly I-C results in increased expression of TNF protein]; Cycloheximide inhibits the reaction [Poly I-C results in increased secretion of TNF protein]; Dimethyl Sulfoxide inhibits the reaction [Poly I-C results in increased secretion of TNF protein]; Ethanol inhibits the reaction [Poly I-C results in increased expression of TNF mRNA]; Ethanol inhibits the reaction [Poly I-C results in increased expression of TNF protein]; Ethanol inhibits the reaction [Poly I-C results in increased secretion of TNF protein]; Ethanol promotes the reaction [Hydroxamic Acids analog promotes the reaction [Dimethyl Sulfoxide inhibits the reaction [Poly I-C results in increased secretion of TNF protein]]]; Hydroxamic Acids analog inhibits the reaction [Poly I-C results in increased secretion of TNF protein]; Hydroxamic Acids analog promotes the reaction [Dimethyl Sulfoxide inhibits the reaction [Poly I-C results in increased secretion of TNF protein]]; Luteolin inhibits the reaction [Poly I-C results in increased expression of TNF mRNA]; Poly I-C promotes the reaction [deoxynivalenol results in increased expression of TNF mRNA]; sodium arsenite inhibits the reaction [Poly I-C results in increased expression of TNF mRNA] | PMID:16687389 PMID:19426678 PMID:19500611 PMID:22319556 PMID:22771370 PMID:25780039 PMID:30726814 | Tnf | increases expression | ISO | TNF (Homo sapiens) | 6480464 | CTD | Poly I-C results in increased expression of TNF mRNA; Poly I-C results in increased expression of TNF protein | PMID:30017638 PMID:36958387 | Tnf | increases expression | ISO | Tnf (Rattus norvegicus) | 6480464 | CTD | Poly I-C results in increased expression of TNF mRNA; Poly I-C results in increased expression of TNF protein | PMID:23939143 PMID:24423102 PMID:28726298 | Tnf | increases secretion | ISO | TNF (Homo sapiens) | 6480464 | CTD | Poly I-C results in increased secretion of TNF protein | PMID:17669408 PMID:17698565 PMID:20932985 PMID:23618096 PMID:27385120 | Tnf | multiple interactions | ISO | TNF (Homo sapiens) | 6480464 | CTD | 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane promotes the reaction [Poly I-C results in increased expression of TNF protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Poly I-C results in increased secretion of TNF protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Poly I-C results in increased secretion of TNF protein]; 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol promotes the reaction [Poly I-C results in increased expression of TNF protein]; [[Poly I-C binds to and results in increased activity of TLR3 protein] which co-treated with Nanotubes, Carbon] results in increased secretion of TNF protein; CEP-11004 inhibits the reaction [Poly I-C results in increased secretion of TNF protein]; CpG ODN 2006 inhibits the reaction [Poly I-C results in increased secretion of TNF protein]; Estradiol promotes the reaction [Poly I-C results in increased expression of TNF protein]; N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide inhibits the reaction [Poly I-C results in increased secretion of TNF protein]; pyrazolanthrone inhibits the reaction [Poly I-C results in increased secretion of TNF protein]; RTKI cpd inhibits the reaction [Poly I-C results in increased secretion of TNF protein]; SB 203580 inhibits the reaction [Poly I-C results in increased secretion of TNF protein] | PMID:17698565 PMID:20932985 PMID:23266719 PMID:30017638 | Tnf | multiple interactions | ISO | Tnf (Rattus norvegicus) | 6480464 | CTD | cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester inhibits the reaction [Poly I-C results in increased expression of TNF mRNA]; MIR26A mRNA inhibits the reaction [Poly I-C results in increased expression of TNF mRNA]; MIR26A mRNA inhibits the reaction [Poly I-C results in increased expression of TNF protein] | PMID:24423102 PMID:28726298 | | ||||||||||||||||||||||
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