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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10552
Species: Mus musculus
RGD Object: Gene
Symbol: Esr2
Name: estrogen receptor 2 (beta)
Acc ID: CHEBI:8434
Term: prochloraz
Definition: A member of the class of ureas that is 1H-imidazole-1-carboxamide substituted by a propyl and a 2-(2,4,6-trichlorophenoxy)ethyl group at the amino nitrogen atom. A fungicide active against a wide range of diseases affecting field crops, fruit, turf and vegetables.
Chemical ID: MESH:C045362
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:692136480464CTDprochloraz results in decreased expression of ESR2 mRNA

PMID:15130599
multiple interactionsISORGD:692136480464CTDfulvestrant inhibits the reaction [prochloraz results in decreased expression of ESR2 mRNA], prochloraz promotes the reaction [Estradiol results in increased expression of ESR2 mRNA]

PMID:15130599, PMID:15261991
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.