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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 71034
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Htr7
Name: 5-hydroxytryptamine receptor 7
Acc ID: CHEBI:83807
Term: paliperidone palmitate
Definition: A racemate comprising equimolar amounts of (R)- and (S)-paliperidone palmitate. A long-acting injectable formulation of paliperidone (the major active metabolite of risperidone) that is used for treatment of schizophrenia.
Chemical ID: MESH:D000068882
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Htr7multiple interactionsISORGD:13469496480464CTD[Paliperidone Palmitate binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP] Paliperidone Palmitate binds to and results in decreased activity of HTR7 protein

PMID:18996971 PMID:19509219 PMID:20827463
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