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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736963
Species: Homo sapiens
RGD Object: Gene
Symbol: TAT
Name: tyrosine aminotransferase
Acc ID: CHEBI:8378
Term: prednisolone
Definition: A glucocorticoid that is prednisone in which the oxo group at position 11 has been reduced to the corresponding beta-hydroxy group. It is a drug metabolite of prednisone.
Chemical ID: MESH:D011239
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TATincreases activityISOTat (Mus musculus)6480464CTDPrednisolone results in increased activity of TAT proteinPMID:14694204
TATincreases activityISOTat (Rattus norvegicus)6480464CTDPrednisolone results in increased activity of TAT proteinPMID:14694204 PMID:15784656 PMID:9259316
TATincreases expressionISOTat (Rattus norvegicus)6480464CTDPrednisolone results in increased expression of TAT mRNAPMID:15784656
TATmultiple interactionsISOTat (Rattus norvegicus)6480464CTD(3b,5b,7a,12a)-7,12-dihydroxy-3-(2-((4-((11b,17b)-17-hydroxy-3-oxo-17-prop-1-ynylestra-4,9-dien-11-yl) phenyl)(methyl)amino)ethoxy)cholan-24-oic acid inhibits the reaction [Prednisolone results in increased activity of TAT protein]; (3b,5b,7a,12a)-7,12-dihydroxy-3-(2-((4-((11b,17b)-17-hydroxy-3-oxo-17-prop-1-ynylestra-4,9-dien-11-yl) phenyl)(methyl)amino)ethoxy)cholan-24-oic acid inhibits the reaction [Prednisolone results in increased expression of TAT mRNA]PMID:15784656
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