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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1353629
Species: Homo sapiens
RGD Object: Gene
Symbol: IL12B
Name: interleukin 12B
Acc ID: CHEBI:8378
Term: prednisolone
Definition: A glucocorticoid that is prednisone in which the oxo group at position 11 has been reduced to the corresponding beta-hydroxy group. It is a drug metabolite of prednisone.
Chemical ID: MESH:D011239
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IL12Bmultiple interactionsEXP 6480464CTDPrednisolone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL12B protein]PMID:36416909
IL12Bdecreases secretionISOIl12b (Mus musculus)6480464CTDPrednisolone results in decreased secretion of IL12B proteinPMID:28003376
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