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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352097
Species: Homo sapiens
RGD Object: Gene
Symbol: POMC
Name: proopiomelanocortin
Acc ID: CHEBI:8378
Term: prednisolone
Definition: A glucocorticoid that is prednisone in which the oxo group at position 11 has been reduced to the corresponding beta-hydroxy group. It is a drug metabolite of prednisone.
Chemical ID: MESH:D011239
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
POMCdecreases expressionISOPomc (Rattus norvegicus)6480464CTDPrednisolone results in decreased expression of POMC protein; Prednisolone results in decreased expression of POMC protein modified formPMID:14694204 PMID:9625448
POMCmultiple interactionsISOPomc (Rattus norvegicus)6480464CTDsairei-to inhibits the reaction [Prednisolone results in decreased expression of POMC protein modified form]PMID:9625448
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