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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69313
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ache
Name: acetylcholinesterase
Acc ID: CHEBI:8354
Term: pralidoxime
Definition: A pyridinium ion that is 1-methylpyridinium substituted by a (hydroxyimino)methyl group at position 2.
Chemical ID: MESH:C028797
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Achemultiple interactionsEXP 6480464CTD[Methyl Parathion co-treated with pralidoxime co-treated with Atropine] results in decreased expression of ACHE protein, [Methyl Parathion co-treated with pralidoxime] results in decreased expression of ACHE protein, [Paraoxon co-treated with pralidoxime co-treated with Atropine] results in decreased activity of ACHE protein, [pralidoxime co-treated with Atropine] inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein], Obidoxime Chloride inhibits the reaction [[Paraoxon co-treated with pralidoxime co-treated with Atropine] results in decreased activity of ACHE protein], pralidoxime inhibits the reaction [Paraoxon results in decreased activity of ACHE protein], pralidoxime inhibits the reaction [Sarin analog results in decreased activity of ACHE protein], pralidoxime inhibits the reaction [Sarin results in decreased activity of ACHE protein], pralidoxime inhibits the reaction [VX analog results in decreased activity of ACHE protein], pralidoxime promotes the reaction [[Atropine co-treated with Curcumin] inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]]

PMID:15669039, PMID:16025528, PMID:17963125, PMID:20971170, PMID:22783142, PMID:23123249, PMID:26751814
Acheaffects bindingISORGD:7358786480464CTDpralidoxime binds to ACHE protein

PMID:20412789
Achemultiple interactionsISORGD:7358786480464CTDpralidoxime inhibits the reaction [Chlorfenvinphos results in decreased activity of ACHE protein], pralidoxime inhibits the reaction [Chlorpyrifos results in decreased activity of ACHE protein], pralidoxime inhibits the reaction [Cholinesterase Inhibitors binds to and results in decreased activity of ACHE protein], pralidoxime inhibits the reaction [cyclohexyl methylphosphonofluoridate binds to and results in decreased activity of ACHE protein], pralidoxime inhibits the reaction [cyclohexyl methylphosphonofluoridate results in decreased activity of ACHE protein], pralidoxime inhibits the reaction [Diazinon results in decreased activity of ACHE protein], pralidoxime inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein], pralidoxime inhibits the reaction [dicrotophos results in decreased activity of ACHE protein], pralidoxime inhibits the reaction [Dimethoate results in decreased activity of ACHE protein], pralidoxime inhibits the reaction [dimethoxon results in decreased activity of ACHE protein], pralidoxime inhibits the reaction [ethylparaoxon results in decreased activity of ACHE protein], pralidoxime inhibits the reaction [heptenophos results in decreased activity of ACHE protein], pralidoxime inhibits the reaction [Isoflurophate results in decreased activity of ACHE protein], pralidoxime inhibits the reaction [leptophos oxon results in decreased activity of ACHE protein], pralidoxime inhibits the reaction [malaoxon results in decreased activity of ACHE protein], pralidoxime inhibits the reaction [Malathion results in decreased activity of ACHE protein], pralidoxime inhibits the reaction [methamidophos results in decreased activity of ACHE protein], pralidoxime inhibits the reaction [methyl demeton results in decreased activity of ACHE protein], pralidoxime inhibits the reaction [methylparaoxon results in decreased activity of ACHE protein], pralidoxime inhibits the reaction [Mevinphos results in decreased activity of ACHE protein], pralidoxime inhibits the reaction [Monocrotophos results in decreased activity of ACHE protein], pralidoxime inhibits the reaction [Obidoxime Chloride results in decreased activity of ACHE protein], pralidoxime inhibits the reaction [Organophosphates binds to and results in decreased activity of ACHE protein], pralidoxime inhibits the reaction [Organophosphorus Compounds results in decreased activity of ACHE protein], pralidoxime inhibits the reaction [Paraoxon binds to and results in decreased activity of ACHE protein], pralidoxime inhibits the reaction [Paraoxon results in decreased activity of ACHE protein mutant form], pralidoxime inhibits the reaction [Paraoxon results in decreased activity of ACHE protein], pralidoxime inhibits the reaction [Phosphamidon results in decreased activity of ACHE protein], pralidoxime inhibits the reaction [S-(N, N-diethylaminoethyl) isobutyl methylphosphothiolate results in decreased activity of ACHE protein], pralidoxime inhibits the reaction [Sarin analog results in decreased activity of ACHE protein], pralidoxime inhibits the reaction [Sarin binds to and results in decreased activity of ACHE protein], pralidoxime inhibits the reaction [Sarin results in decreased activity of ACHE protein], pralidoxime inhibits the reaction [Soman results in decreased activity of ACHE protein], pralidoxime inhibits the reaction [tabun binds to and results in decreased activity of ACHE protein], pralidoxime inhibits the reaction [tabun results in decreased activity of ACHE protein mutant form], pralidoxime inhibits the reaction [tabun results in decreased activity of ACHE protein], pralidoxime inhibits the reaction [Trichlorfon results in decreased activity of ACHE protein], pralidoxime inhibits the reaction [VX analog results in decreased activity of ACHE protein], pralidoxime inhibits the reaction [VX binds to and results in decreased activity of ACHE protein], pralidoxime inhibits the reaction [VX results in decreased activity of ACHE protein], pralidoxime metabolite inhibits the reaction [Sarin results in decreased activity of ACHE protein], pralidoxime metabolite inhibits the reaction [VX results in decreased activity of ACHE protein], pralidoxime promotes the reaction [Carbaryl results in decreased activity of ACHE protein], pralidoxime promotes the reaction [Propoxur results in decreased activity of ACHE protein]

PMID:1494302, PMID:16112538, PMID:17265452, PMID:18070496, PMID:18344198, PMID:18804659, PMID:19917271, PMID:20096273, PMID:20156430, PMID:20227398, PMID:20382137, PMID:20433814, PMID:20688148, PMID:20971170, PMID:21673941, PMID:21983245, PMID:22960624, PMID:22975155, PMID:23073172, PMID:23111374, PMID:23962483, PMID:25451328, PMID:25743373, PMID:26070418, PMID:26210933, PMID:26368669, PMID:27129421, PMID:27138243, PMID:27551891, PMID:29614332, PMID:29920286, PMID:31276662, PMID:8134223, PMID:8783813
Achemultiple interactionsISORGD:7358796480464CTDpralidoxime binds to and results in decreased activity of ACHE protein, pralidoxime inhibits the reaction [malaoxon results in decreased activity of ACHE protein], pralidoxime inhibits the reaction [Malathion results in decreased activity of ACHE protein], pralidoxime inhibits the reaction [tabun results in decreased activity of ACHE protein]

PMID:16598855, PMID:20406208, PMID:21723318, PMID:29772260
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.