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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619996
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bche
Name: butyrylcholinesterase
Acc ID: CHEBI:8354
Term: pralidoxime
Definition: A pyridinium ion that is 1-methylpyridinium substituted by a (hydroxyimino)methyl group at position 2.
Chemical ID: MESH:C028797
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bchemultiple interactionsEXP 6480464CTD[Atropine co-treated with pralidoxime] results in decreased expression of BCHE protein, [Methyl Parathion co-treated with pralidoxime co-treated with Atropine] results in decreased expression of BCHE protein, [Methyl Parathion co-treated with pralidoxime] results in decreased expression of BCHE protein, pralidoxime affects the reaction [4-nitrophenyl 2-propylmethylphosphonate results in decreased activity of BCHE protein], pralidoxime affects the reaction [ethyl 4-nitrophenyl methylphosphonate results in decreased activity of BCHE protein]

PMID:17963125, PMID:26705700
Bcheaffects bindingISORGD:7321746480464CTDBCHE protein binds to pralidoxime

PMID:22922115
Bchemultiple interactionsISORGD:7321746480464CTDpralidoxime binds to and affects the activity of BCHE protein, pralidoxime inhibits the reaction [Chlorpyrifos results in decreased activity of BCHE protein], pralidoxime inhibits the reaction [Cholinesterase Inhibitors binds to and results in decreased activity of BCHE protein], pralidoxime inhibits the reaction [Dichlorvos results in decreased activity of BCHE protein], pralidoxime inhibits the reaction [Isoflurophate inhibits the reaction [BCHE protein results in increased hydrolysis of Butyrylthiocholine]], pralidoxime inhibits the reaction [Isoflurophate results in decreased activity of BCHE protein], pralidoxime inhibits the reaction [Organophosphates binds to and results in decreased activity of BCHE protein], pralidoxime inhibits the reaction [Paraoxon results in decreased activity of BCHE protein], pralidoxime inhibits the reaction [quinalphos results in decreased activity of BCHE protein], pralidoxime inhibits the reaction [Sarin analog inhibits the reaction [BCHE protein results in increased hydrolysis of Butyrylthiocholine]], pralidoxime inhibits the reaction [Sarin analog results in decreased activity of BCHE protein], pralidoxime inhibits the reaction [Trichlorfon results in decreased activity of BCHE protein], pralidoxime inhibits the reaction [VX analog results in decreased activity of BCHE protein]

PMID:18825528, PMID:20227398, PMID:21802514, PMID:24052565, PMID:27551891, PMID:29614332, PMID:29920286, PMID:31173753, PMID:32278739, PMID:423703
Bchemultiple interactionsISORGD:7321756480464CTDpralidoxime binds to and results in decreased activity of BCHE protein

PMID:16598855
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.