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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733394
Species: Mus musculus
RGD Object: Gene
Symbol: Tas1r3
Name: taste receptor, type 1, member 3
Acc ID: CHEBI:83535
Term: neohesperidin dihydrochalcone
Definition: A member of the dihydrochalcones that is 3,2',4',6'-tetrahydroxy-4-methoxydihydrochalcone attached to a neohesperidosyl residue at position 4' via glycosidic linkage. It is found in sweet orange.
Chemical ID: MESH:C013613
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tas1r3affects bindingISOTAS1R3 (Homo sapiens)6480464CTDneohesperidin dihydrochalcone binds to TAS1R3 proteinPMID:17935609
Tas1r3multiple interactionsISOTAS1R3 (Homo sapiens)6480464CTDlactisole inhibits the reaction [neohesperidin dihydrochalcone results in increased activity of [TAS1R3 protein binds to TAS1R2 protein]]; neohesperidin dihydrochalcone binds to and results in increased activity of TAS1R3 protein; neohesperidin dihydrochalcone results in increased activity of [TAS1R3 protein binds to TAS1R2 protein]PMID:17935609 PMID:20173092
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