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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61898
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Maoa
Name: monoamine oxidase A
Acc ID: CHEBI:83531
Term: moclobemide
Definition: A member of the class of benzamides that is benzamide substituted by a chloro group at position 4 and a 2-(morpholin-4-yl)ethyl group at the nitrogen atom. It acts as a reversible monoamine oxidase inhibitor and is used in the treatment of depression.
Chemical ID: MESH:D020912
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Maoadecreases activityEXP 6480464CTDMoclobemide results in decreased activity of MAOA proteinPMID:15178694 PMID:15545290
Maoadecreases activityISOMaoa (Mus musculus)6480464CTDMoclobemide results in decreased activity of MAOA proteinPMID:23943324
Maoadecreases activityISOMAOA (Homo sapiens)6480464CTDMoclobemide results in decreased activity of MAOA proteinPMID:21923181
Maoamultiple interactionsISOMAOA (Homo sapiens)6480464CTDMoclobemide inhibits the reaction [MAOA protein results in decreased amination of Serotonin]PMID:26721607
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