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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70896
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ces1d
Name: carboxylesterase 1D
Acc ID: CHEBI:83481
Term: ritalinic acid
Definition: A monocarboxylic acid that is phenylacetic acid substituted by a piperidin-2-yl group at position 2. It is a metabolite of the drug methylphenidate.
Chemical ID: MESH:C009189
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ces1dincreases chemical synthesisISORGD:13529606480464CTDCES1 protein results in increased chemical synthesis of ritalinic acid

PMID:20097249
Ces1dmultiple interactionsISORGD:13529606480464CTD[CES1 protein results in increased hydrolysis of Methylphenidate] which results in increased chemical synthesis of ritalinic acid

PMID:20097249
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