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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2060
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Adrb2
Name: adrenoceptor beta 2
Acc ID: CHEBI:82700
Term: olodaterol
Definition: A member of the class of benzoxazine that is 6-hydroxy-1,4-benzoxazin-3-one in which the hydrogen at position 4 is replaced by a (1R)-1-hydroxy-2-{[1-(4-methoxyphenyl)-2-methylpropan-2-yl]amino}ethyl group. Used (as its hydrochloride salt) for long-term treatment of airflow obstruction in patients with chronic obstructive pulmonary disease including chronic bronchitis and/or emphysema.
Chemical ID: MESH:C549647
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Adrb2affects expressionISORGD:7335956480464CTDolodaterol affects the expression of ADRB2 mRNA

PMID:24705868
Adrb2increases expressionISORGD:7335956480464CTDolodaterol results in increased expression of ADRB2 mRNA

PMID:22483689
Adrb2multiple interactionsISORGD:7335956480464CTDCycloheximide inhibits the reaction [olodaterol affects the expression of ADRB2 mRNA] EDN1 protein promotes the reaction [olodaterol results in increased expression of ADRB2 mRNA] ICI 118551 inhibits the reaction [olodaterol affects the expression of ADRB2 mRNA] olodaterol promotes the reaction [EDN1 protein results in increased expression of ADRB2 mRNA]

PMID:22483689 PMID:24705868
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