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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620180
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc40a1
Name: solute carrier family 40 member 1
Acc ID: CHEBI:82664
Term: iron(0)
Definition: An elemental iron in which the atom has an oxidation state of zero.
Chemical ID: MESH:D007501
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDIron results in decreased expression of SLC40A1 protein

PMID:22659129
increases expressionEXP 6480464CTDIron deficiency results in increased expression of SLC40A1 mRNA

PMID:19821111, PMID:21540277
affects metabolic processingISORGD:7330736480464CTDSLC40A1 protein affects the metabolism of Iron

PMID:17194590
decreases exportISORGD:7330736480464CTDSLC40A1 protein mutant form results in decreased export of Iron

PMID:16457665
decreases expressionISORGD:7330736480464CTDIron results in decreased expression of SLC40A1 protein

PMID:22659129
increases exportISORGD:7330736480464CTDSLC40A1 protein mutant form results in increased export of Iron, SLC40A1 protein results in increased export of Iron

PMID:16457665, PMID:21303654
increases expressionISORGD:7330736480464CTDIron deficiency results in increased expression of SLC40A1 mRNA, Iron results in increased expression of SLC40A1 mRNA

PMID:16565419, PMID:16648237, PMID:18648087, PMID:23776592
multiple interactionsISORGD:7330726480464CTD[CP protein results in increased oxidation of Iron] which results in increased stability of SLC40A1 protein, Iron affects the reaction [HAMP protein results in increased uptake of SLC40A1 protein], Iron inhibits the reaction [SLC40A1 protein results in increased export of Manganese]

PMID:20655381, PMID:22178646
multiple interactionsISORGD:7330736480464CTD[HBB-B1 gene mutant form results in increased abundance of Iron] which results in increased expression of SLC40A1 mRNA, [HBB-B2 gene mutant form results in increased abundance of Iron] which results in increased expression of SLC40A1 mRNA, Iron inhibits the reaction [Diethylnitrosamine results in decreased expression of SLC40A1 mRNA], NFE2L2 protein promotes the reaction [SLC40A1 protein results in increased export of Iron], SLC40A1 protein inhibits the reaction [ferrous sulfate results in increased uptake of Iron]

PMID:17018382, PMID:19061943, PMID:19913091, PMID:21303654
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.