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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1345296
Species: Homo sapiens
RGD Object: Gene
Symbol: HFE
Name: homeostatic iron regulator
Acc ID: CHEBI:82664
Term: iron(0)
Definition: An elemental iron in which the atom has an oxidation state of zero.
Chemical ID: MESH:D007501
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HFEaffects abundanceEXP 6480464CTDHFE gene polymorphism affects the abundance of Iron; HFE protein affects the abundance of IronPMID:12393473 PMID:16877869
HFEaffects response to substanceEXP 6480464CTDHFE protein affects the susceptibility to IronPMID:16893896
HFEdecreases uptakeEXP 6480464CTDHFE protein results in decreased uptake of IronPMID:16823846 PMID:16841247
HFEincreases abundanceEXP 6480464CTDHFE gene mutant form results in increased abundance of Iron; HFE gene polymorphism results in increased abundance of IronPMID:17047092 PMID:17101320
HFEincreases uptakeEXP 6480464CTDHFE gene mutant form results in increased uptake of IronPMID:17101320
HFEmultiple interactionsEXP 6480464CTD[HFE protein binds to B2M protein binds to SLC11A2 protein] which results in decreased uptake of Iron; [HFE protein binds to TFR2 protein] which affects the susceptibility to Iron; HFE protein inhibits the reaction [TFRC protein results in increased uptake of Iron]; TNF gene SNP promotes the reaction [HFE protein mutant form results in increased uptake of Iron]PMID:10085150 PMID:16793930 PMID:16841247 PMID:16893896
HFEaffects abundanceISOHfe (Mus musculus)6480464CTDHFE protein affects the abundance of IronPMID:18317567
HFEaffects metabolic processingISOHfe (Mus musculus)6480464CTDHFE protein affects the metabolism of IronPMID:17194590
HFEmultiple interactionsISOHfe (Mus musculus)6480464CTD[HFE gene mutant form co-treated with TFR2 gene mutant form] results in increased abundance of IronPMID:22383097
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