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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10510
Species: Mus musculus
RGD Object: Gene
Symbol: Egf
Name: epidermal growth factor
Acc ID: CHEBI:82619
Term: icariside II
Definition: A glycosyloxyflavone that is 3,5,7-trihydroxy-4'-methoxy-8-prenylflavone in which the hydroxy group at position 3 has been converted to its alpha-L-rhamnopyranoside.
Chemical ID: MESH:C060988
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:7368326480464CTDbaohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein], baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of AKT1S1 protein], baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of BRAF protein], baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein], baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein], baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein], baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of MTOR protein]

PMID:25119583
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.