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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621821
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fen1
Name: flap structure-specific endonuclease 1
Acc ID: CHEBI:8249
Term: piroxicam
Definition: A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylic acid 1,1-dioxide with the exocyclic nitrogen of 2-aminopyridine. A non-steroidal anti-inflammatory drug of the oxicam class, it is used to relieve pain and works by preventing the production of endogenous prostaglandins involved in the mediation of pain, stiffness, tenderness and swelling.
Chemical ID: MESH:D010894
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fen1decreases expressionISOFEN1 (Homo sapiens)6480464CTDPiroxicam results in decreased expression of FEN1 mRNAPMID:21858171
Fen1multiple interactionsISOFEN1 (Homo sapiens)6480464CTDCisplatin inhibits the reaction [Piroxicam results in decreased expression of FEN1 mRNA]PMID:21858171
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