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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62037
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Arc
Name: activity-regulated cytoskeleton-associated protein
Acc ID: CHEBI:8249
Term: piroxicam
Definition: A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylic acid 1,1-dioxide with the exocyclic nitrogen of 2-aminopyridine. A non-steroidal anti-inflammatory drug of the oxicam class, it is used to relieve pain and works by preventing the production of endogenous prostaglandins involved in the mediation of pain, stiffness, tenderness and swelling.
Chemical ID: MESH:D010894
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Arcmultiple interactionsISOARC (Homo sapiens)6480464CTD[Piroxicam co-treated with Cisplatin] results in decreased expression of ARC mRNAPMID:21858171
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