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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309614
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dtymk
Name: deoxythymidylate kinase
Acc ID: CHEBI:8249
Term: piroxicam
Definition: A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylic acid 1,1-dioxide with the exocyclic nitrogen of 2-aminopyridine. A non-steroidal anti-inflammatory drug of the oxicam class, it is used to relieve pain and works by preventing the production of endogenous prostaglandins involved in the mediation of pain, stiffness, tenderness and swelling.
Chemical ID: MESH:D010894
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dtymkdecreases expressionISODTYMK (Homo sapiens)6480464CTDPiroxicam results in decreased expression of DTYMK mRNAPMID:21858171
Dtymkmultiple interactionsISODTYMK (Homo sapiens)6480464CTDCisplatin promotes the reaction [Piroxicam results in decreased expression of DTYMK mRNA]PMID:21858171
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