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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306537
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Vps28
Name: VPS28 subunit of ESCRT-I
Acc ID: CHEBI:8249
Term: piroxicam
Definition: A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylic acid 1,1-dioxide with the exocyclic nitrogen of 2-aminopyridine. A non-steroidal anti-inflammatory drug of the oxicam class, it is used to relieve pain and works by preventing the production of endogenous prostaglandins involved in the mediation of pain, stiffness, tenderness and swelling.
Chemical ID: MESH:D010894
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:13152106480464CTDPiroxicam results in decreased expression of VPS28 mRNA

PMID:21858171
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.