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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305747
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Stat4
Name: signal transducer and activator of transcription 4
Acc ID: CHEBI:8249
Term: piroxicam
Definition: A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylic acid 1,1-dioxide with the exocyclic nitrogen of 2-aminopyridine. A non-steroidal anti-inflammatory drug of the oxicam class, it is used to relieve pain and works by preventing the production of endogenous prostaglandins involved in the mediation of pain, stiffness, tenderness and swelling.
Chemical ID: MESH:D010894
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Stat4decreases expressionISOSTAT4 (Homo sapiens)6480464CTDPiroxicam results in decreased expression of STAT4 mRNAPMID:19192274
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