GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1304659
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Arhgef2
Name: Rho/Rac guanine nucleotide exchange factor 2
Acc ID: CHEBI:8249
Term: piroxicam
Definition: A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylic acid 1,1-dioxide with the exocyclic nitrogen of 2-aminopyridine. A non-steroidal anti-inflammatory drug of the oxicam class, it is used to relieve pain and works by preventing the production of endogenous prostaglandins involved in the mediation of pain, stiffness, tenderness and swelling.
Chemical ID: MESH:D010894
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:13122266480464CTDPiroxicam results in decreased expression of ARHGEF2 mRNA

PMID:21858171
multiple interactionsISORGD:13122266480464CTDCisplatin inhibits the reaction [Piroxicam results in decreased expression of ARHGEF2 mRNA]

PMID:21858171
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.