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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11219
Species: Mus musculus
RGD Object: Gene
Symbol: Rb1
Name: RB transcriptional corepressor 1
Acc ID: CHEBI:8249
Term: piroxicam
Definition: A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylic acid 1,1-dioxide with the exocyclic nitrogen of 2-aminopyridine. A non-steroidal anti-inflammatory drug of the oxicam class, it is used to relieve pain and works by preventing the production of endogenous prostaglandins involved in the mediation of pain, stiffness, tenderness and swelling.
Chemical ID: MESH:D010894
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rb1decreases expressionISORB1 (Homo sapiens)6480464CTDPiroxicam results in decreased expression of RB1 mRNAPMID:21858171
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