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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10436
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Acc ID: CHEBI:82437
Term: Dibenz[a,c]anthracene
Definition: A carbopolycyclic compound that has formula C22H14.
Chemical ID: MESH:C006710
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a1increases expressionEXP 6480464CTDbenzotriphenylene results in increased expression of CYP1A1 mRNAPMID:1497680 PMID:8190110 PMID:9496914
Cyp1a1multiple interactionsEXP 6480464CTDbenzotriphenylene results in increased expression of and results in increased activity of CYP1A1 protein; Nocodazole inhibits the reaction [benzotriphenylene results in increased expression of and results in increased activity of CYP1A1 protein]; Nocodazole inhibits the reaction [benzotriphenylene results in increased expression of CYP1A1 mRNA]; Tetradecanoylphorbol Acetate inhibits the reaction [benzotriphenylene results in increased expression of CYP1A1 mRNA]PMID:1497680 PMID:8190110 PMID:9496914
Cyp1a1increases expressionISOCyp1a1 (Rattus norvegicus)6480464CTDbenzotriphenylene results in increased expression of CYP1A1 proteinPMID:28104439
Cyp1a1increases expressionISOCYP1A1 (Homo sapiens)6480464CTDbenzotriphenylene results in increased expression of CYP1A1 mRNAPMID:17253728
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