GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | CYP1A2 | increases expression | EXP | | 6480464 | CTD | 2-amino-3-methyl-9H-pyrido(2,3-b)indole results in increased expression of CYP1A2 mRNA | PMID:27644595 | CYP1A2 | multiple interactions | EXP | | 6480464 | CTD | CYP1A2 protein results in increased activity of and results in increased hydroxylation of 2-amino-3-methyl-9H-pyrido(2,3-b)indole; CYP1A2 protein results in increased metabolism of and results in increased susceptibility to 2-amino-3-methyl-9H-pyrido(2,3-b)indole | PMID:14729582 PMID:28160022 | CYP1A2 | increases expression | ISO | Cyp1a2 (Rattus norvegicus) | 6480464 | CTD | 2-amino-3-methyl-9H-pyrido(2,3-b)indole results in increased expression of CYP1A2 mRNA; 2-amino-3-methyl-9H-pyrido(2,3-b)indole results in increased expression of CYP1A2 protein | PMID:8902619 | CYP1A2 | multiple interactions | ISO | Cyp1a2 (Rattus norvegicus) | 6480464 | CTD | lead nitrate inhibits the reaction [2-amino-3-methyl-9H-pyrido(2,3-b)indole results in increased expression of CYP1A2 mRNA]; lead nitrate inhibits the reaction [2-amino-3-methyl-9H-pyrido(2,3-b)indole results in increased expression of CYP1A2 protein] | PMID:8902619 | |
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