Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10436
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Acc ID: CHEBI:82335
Term: Indeno[1,2,3-cd]pyrene
Definition: A pyrene that has formula C22H12.
Chemical ID: MESH:C041508
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a1increases expressionEXP 6480464CTDindeno(1,2,3-cd)pyrene results in increased expression of CYP1A1 proteinPMID:26377693
Cyp1a1multiple interactionsEXP 6480464CTD[indeno(1,2,3-cd)pyrene co-treated with Antigens, Dermatophagoides] results in increased expression of CYP1A1 mRNAPMID:36975775
Cyp1a1increases activityISOCyp1a1 (Rattus norvegicus)6480464CTDindeno(1,2,3-cd)pyrene results in increased activity of CYP1A1 proteinPMID:10190573
Cyp1a1increases expressionISOCYP1A1 (Homo sapiens)6480464CTDindeno(1,2,3-cd)pyrene results in increased expression of CYP1A1 mRNA; indeno(1,2,3-cd)pyrene results in increased expression of CYP1A1 proteinPMID:17253728 PMID:19463884 PMID:21781905 PMID:27196671 PMID:32251684
Cyp1a1multiple interactionsISOCYP1A1 (Homo sapiens)6480464CTDDexamethasone inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of CYP1A1 protein]; indeno(1,2,3-cd)pyrene promotes the reaction [AHR protein results in increased expression of CYP1A1 mRNA]PMID:19463884 PMID:21781905
Go Back to source page   Continue to Ontology report